Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis The CLASS Study: A Randomized Controlled Trial
نویسنده
چکیده
FOR PATIENTS WITH MUSCULOskeletal disorders, convent ional nonsteroidal anti inflammatory drugs (NSAIDs) are a mainstay of clinical care. Wellestablished limitations of NSAID therapy, however, include the risk of developing significant injury to the upper gastrointestinal (GI) tract. The annualized incidence rate of symptomatic GI ulcers and ulcer complications in NSAID users ranges from 2% to 4% (1%-2% for ulcer complications alone). NSAID-related ulcer complications are estimated to lead to
منابع مشابه
Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.
CONTEXT In vitro studies have shown that celecoxib inhibits cyclooxygenase 2 (COX-2) but not COX-1, suggesting that this drug may have anti-inflammatory and analgesic activity without adverse upper gastrointestinal (GI) tract effects that result from COX-1 inhibition. OBJECTIVE To test whether celecoxib has efficacy as an anti-inflammatory and analgesic with reduced GI tract mucosal damage co...
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for treating symptoms of rheumatologic diseases, such as osteoarthritis and rheumatoid arthritis. Knowing their side effects and the way to minimize them is a medical responsibility. To reduce NSAID-related risk, clinicians should choose a gastroprotective strategy. This may include coprescribing a traditional NSAID with a proton pum...
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